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Multiple Sclerosis Info
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Thursday, May 8
by
multiplesclerosis
on Thu 08 May 2008 02:00 AM CST
Authors from the VA North Texas Health Care System Neurology Section and the Department of Neurology at the University of Texas Southwestern Medical Center at Dallas have highlighted the potential benefits for DNA-based vaccine administration in more »
Tuesday, May 6
by
multiplesclerosis
on Tue 06 May 2008 08:16 AM CST
ZymoGenetics, Inc. (NASDAQ:ZGEN), announced that its development partner Merck Serono, a division of Merck KGaA, Darmstadt, Germany, has initiated a Phase 2 clinical trial to more »
Thursday, April 24
by
multiplesclerosis
on Thu 24 Apr 2008 02:00 AM CST
Multiple sclerosis is a lifelong, immune-mediated progressive disorder. The early age of onset and the chronic nature of the disease with accumulation of physical disability, demand a long-term ("lifelong") management, including disease-modifying more »
by
multiplesclerosis
on Thu 24 Apr 2008 02:00 AM CST
Botulinum toxin type A injections can decrease spasticity and improve quality of life in multiple sclerosis (MS) patients with spastic foot drop, according to more »
Wednesday, April 23
by
multiplesclerosis
on Wed 23 Apr 2008 09:36 AM CST
Pluristem Therapeutics Inc. (NASDAQ:PSTI) (DAX:PJT) a bio-therapeutics company dedicated to the commercialization of non-personalized (allogeneic) [1] cell therapy products for a variety of degenerative, ischemic and autoimmune indications, announced today that a preclinical study utilizing the more »
Tuesday, April 22
by
multiplesclerosis
on Tue 22 Apr 2008 09:31 AM CST
The investigational oral therapy FTY720 (fingolimod) continues to demonstrate sustained benefits in patients with multiple sclerosis (MS) after three years of treatment, according to new more »
Saturday, April 19
by
multiplesclerosis
on Sat 19 Apr 2008 10:14 AM CST
Genentech, Inc. (NYSE: DNA) and Biogen Idec, Inc. (Nasdaq: BIIB) today announced that a Phase II/III study of Rituxan® (rituximab) for primary-progressive multiple sclerosis (PPMS) did not meet its primary endpoint as measured by the time to more »
Thursday, April 10
by
multiplesclerosis
on Thu 10 Apr 2008 11:30 AM CST
MediciNova reports encouraging results from Phase II multiple sclerosis trial MediciNova has announced positive clinical findings from the completed two-year Phase II clinical trial of orally administered MN-166 for the treatment of multiple sclerosis. The data showed that sustained disability progression was significantly less likely (by approximately 50%) in those patients receiving MN-166 at either 30 or 60mg per day for 24 months than in those patients receiving the drug for 12 months (p=0.026). The clinical trial demonstrated that the significant reduction in brain volume loss (p=0.035), as measured by cranial magnetic resonance imaging (MRI) scans, observed after 12 months in patients treated with 60mg per day of MN-166 compared to placebo were again demonstrated in year two of the study. Brain volume loss was significantly less (p=0.030) in patients receiving 60mg per day of MN-166 for 24 months compared to the other treatment groups. The data also showed that MN-166 treatment at 60mg per day significantly reduced the relative risk for conversion of new inflammatory lesions identified at month two to Persistent Black Holes (PBH), an MRI indicator of neuronal loss, eight months later at month ten by 37% (p=0.011); such lesions that remain unchanged for eight months are considered PBHs as compared to transient inflammatory lesions that are more closely associated with relapses. MN-166 treatment at 30mg per day resulted in a trend toward reducing evolution to PBH (p=0.074). Loss of brain volume and development of PBHs on MRI have been shown to correlate with clinical progression and disability in MS patients. Wednesday, April 2
by
multiplesclerosis
on Wed 02 Apr 2008 12:00 AM CST
MBP8298 is a synthetic peptide that consists of 17 amino acids linked in a sequence identical to that of a portion of human myelin basic myelin basic protein (MBP). MBP8298 has been developed for the treatment of multiple sclerosis (MS), and is based on over 26 years of research more »
Wednesday, March 26
by
multiplesclerosis
on Wed 26 Mar 2008 10:58 AM CST
An international panel met in Washington, DC, recently under the auspices of the National MS Society’s International Advisory Committee on Clinical Trials in MS to discuss the ethics of conducting placebo-controlled trials in multiple sclerosis. This has become of increasing concern now more »
Friday, March 21
by
multiplesclerosis
on Fri 21 Mar 2008 12:00 AM CST
The Phase I single ascending dose, double blind placebo controlled randomized study involved 56 healthy volunteers who received the drug in more »
Wednesday, March 12
by
multiplesclerosis
on Wed 12 Mar 2008 07:38 AM CST
RTL1000 is a new agent that has not been previously tested in humans. It is thought that RTL may specifically control the abnormal immune response or attack against the insulation on the nerves more »
Saturday, March 8
by
multiplesclerosis
on Sat 08 Mar 2008 07:00 AM CST
new drug pixantrone would be studied in a multi-center phase I/II trial for treating multiple sclerosis. The company intends to more »
Friday, March 7
by
multiplesclerosis
on Fri 07 Mar 2008 07:04 AM CST
placebo-controlled study will assess the safety profiles of single and multiple oral doses in healthy volunteers.
"The effective treatment of multiple sclerosis remains a more »
by
multiplesclerosis
on Fri 07 Mar 2008 06:44 AM CST
the independent Data Safety Monitoring Board (DSMB) for the Company's phase II MINDSET-01 trial of MBP8298 in patients with relapsing-remitting MS has completed a safety analysis and recommended that the trial continue as more »
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