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  • View Article  Possible link between exposure to aluminium and MS
    Their research has demonstrated very high (up to 40 times the control level) urinary excretion of aluminium in MS, particularly so in the relapsing-remitting form of the disease. Urinary excretion of iron was    more »
    View Article  MRI findings predict evolution of preclinical multiple sclerosis
    Patients with subclinical demyelinating lesions fulfilling MRI Barkhof-TintorĂ© criteria with a normal neurological examination are likely to develop multiple sclerosis (MS), according to a report in the Journal of   more »
    View Article  Closer to Cure for Multiple Sclerosis and Other Myelin- related Diseases
    A breakthrough finding on the mechanism of myelin formation could have a major impact on the treatment of diseases such as multiple sclerosis and demyelination as a result of    more »
    View Article  Type 1 Diabetes and Multiple Sclerosis - Danish Study
    Type 1 diabetes mellitus (T1D) and multiple sclerosis (MS) contribute considerably to the burden of autoimmune diseases in young adults. Although HLA patterns of T1D and MS are considered mutually exclusive, individual and familial co-occurrence    more »
    View Article  Relation of vision to global and regional brain MRI in multiple sclerosis
    Objective: To examine the relation between low-contrast letter acuity, an emerging visual outcome for multiple sclerosis (MS) clinical trials, and   more »
    View Article  Study - Altered functional and structural connectivities in patients with MS
    OBJECTIVE: To determine the functional and structural substrates of motor network dysfunction in patients with   more »
    View Article  Natural History of Multiple Sclerosis with Childhood Onset

    Natural History of Multiple Sclerosis with Childhood Onset

      

    Background

    The course and prognosis of childhood-onset multiplesclerosis have not been well described. 

    Methods...   more »

    View Article  Differences in Damage and Distribution of White Matter Lesions Between Patients With PPMS and RRMS
    Several studies have reported lower focal demyelination and inflammatory activity in primary progressive multiple sclerosis (PPMS) than in relapsing-remitting MS (RRMS). However,   more »
    View Article  Magnetization transfer ratio evolution with demyelination and remyelination
    OBJECTIVE: To assess demyelination and remyelination in vivo (experimentation done in or on the living tissue) in acute gadolinium (Gd)-enhancing lesions of multiple sclerosis (MS). METHODS: We measured   more »
    View Article  Selective association of multiple sclerosis with infectious mononucleosis.

    Selective association of multiple sclerosis with infectious mononucleosis.

    Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this association or its selectivity have been conflicting.  In this study we have evaluated the association between MS and a variety of common childhood infections and afflictions in a large population-based case-control study involving

     

    o     2877 MS cases and

    o     2673 controls in the Netherlands.

     

    We examined the frequency of different common infections and afflictions before the age of 25 and the age at which they occurred, using a self-administered questionnaire.  The Odds ratios (ORs) for the occurrence of a variety of clinically manifest common childhood infections including rubella, measles, chicken pox, and mumps before the age of 25 for MS cases versus controls ranged between 1.14 and 1.42, values similar to those for irrelevant probe variables used to reveal recall bias.

     

    In contrast, the OR for clinically manifest IM in MS cases versus controls, corrected for demographic variables, was 2.22 (95% confidence interval 1.73 2.86; P <0.001).

     

    The average age of onset of IM in the population of MS cases (16.5 years) did not differ from controls (16.8 years).  Our data confirm previous much smaller studies to show that the risk for MS is significantly enhanced by prior IM, and extend those previous data by showing that this association is far stronger than with other common childhood infections or afflictions.

    Department of Prevention and Care,

    TNO Quality of Life,

    Leiden, The Netherlands and

    Netherlands Interdisciplinary Demographic Institute,

    The Hague,

    The Netherlands.
    View Article  Abnormal sensorimotor control, but intact force field adaptation, in multiple sclerosis subjects with no clinical disability.
    In MS subjects with no clinical disability, we assessed sensorimotor organization and their ability to adapt to an unfamiliar dynamical environment. Eleven MS subjects performed reaching movements while   more »
    View Article  Contribution of relapses to disability in multiple sclerosis.
    The impact of relapses on long-term disability in multiple sclerosis remains unclear; however some evidence suggests that relapses play an important role in   more »
    View Article  Immune Police Recognize Good And Bad Guys In The Body

    Immune Police Recognize Good And Bad Guys In The Body

     

    Science Daily —

     

    Immune system police are as good at recognizing bad guys, ...   more »