BHT-3009 is a tolerizing DNA vaccine for MS, encoding full-length human myelin basic protein. Relapsing-remitting MS patients were randomized 1:1:1 into three groups: placebo, 0.5mg BHT-   more »

In our brains, where millions of signals move across a network of neurons like runners in a relay race, all the critical baton passes take place at synapses. These small gaps between nerve cell endings have to be just the right size for messages to transmit   more »

We performed Western blots on CSF from patients with MS and controls with the commercially available Nogo-A antibody and secondary antibody used in a prior report. We used densitometry to measure band density on Western blot. Controls included   more »

"Allowing scientists to further explore this avenue of research may prove to be hugely beneficial not just to the 85,000 people with multiple sclerosis (MS), but to the hundreds of thousands of people living with debilitating, degenerative, and life limiting conditions   more »

Study with Interferon Beta-1b and PMS Induction of serum soluble tumor necrosis factor receptor II (sTNF-RII) and interleukin-1 receptor antagonist (IL-1ra) by interferon beta-1b in patients with progressive multiple   more »

The role of disability and depression in cognitive functioning within 2 years after multiple sclerosis diagnosis. OBJECTIVES : To investigate cognitive functioning shortly after multiple sclerosis (MS) diagnosis and to examine the relationship with   more »

Multiple sclerosis (MS) is an inflammatory autoimmune disease of the central nervous system (CNS), which causes demyelination of axons. Experimental autoimmune encephalomyelitis (EAE) is a mouse model of MS that is induced   more »

The results of an international survey presented by Bayer Schering Pharma shows that many people face the same fears and concerns when they are first diagnosed with multiple s   more »

We are developing Trimesta™ as an oral, immunomodulatory and anti-inflammatory agent for the North American market. Estriol has been approved and marketed throughout Europe and   more »

Authors from the VA North Texas Health Care System Neurology Section and the Department of Neurology at the University of Texas Southwestern Medical Center at Dallas have highlighted the potential benefits for DNA-based vaccine administration in   more »

"Mind games may improve our performance at work", reads the headline in The Times. The newspaper reports that a new study has shown that volunteers who took part in "rigorous   more »

ZymoGenetics, Inc. (NASDAQ:ZGEN), announced that its development partner Merck Serono, a division of Merck KGaA, Darmstadt, Germany, has initiated a Phase 2 clinical trial to   more »

Degeneration of chronically demyelinated axons is a major cause of irreversible neurological decline in the human central nervous system disease, multiple sclerosis (MS). Although the molecular   more »

The antidepressant Prozac may help to curb disease activity in the relapsing remitting form of multiple sclerosis (MS), reveals preliminary research published ahead of print in the Journal of   more »