Currently, there is no single diagnostic test for RLS. The disorder is diagnosed clinically by evaluating the patient's history and symptoms. Despite a clear description of clinical features, the condition   more »

Combination therapies in multiple sclerosis.

 

 

 The last years have seen enormous progress in our understanding of pathophysiology (1) of multiple sclerosis. In addition, the armamentarium (2) of available immunomodulatory or immunosuppressive therapies (3) has greatly increased, especially for the relapsing remitting form of the disease.

 

Since their therapeutic efficacy is often limited in individual patients, it is conceivable that combination therapies may bring improved clinical efficacy while managing increasing side effects and toxicity. The combination of agents with additive or synergistic modes of action is of particular interest. Combination of the two classes of recognised first-line treatment, a beta-interferon and glatiramer acetate is currently under evaluation in a large Phase III trial.

 

However, there are theoretical reasons for thinking that such a combination may not be particularly beneficial. None of the combination studies performed with beta-interferons to date have shown unequivocal evidence of benefit, including combinations with statins, natalizumab, and azathioprine.

 

On the other hand, for glatiramer acetate, the combination with mitoxantrone used as induction therapy may be of interest and preliminary data on combination with minocycline are also promising.

 

University of Bochum,

St. Josef-Hospital,

Dept. of Neurology,

Gudrunstr. 56, 44791,

Bochum, Germany.

 

 

Terms:

1. pathophysiology - The study of such changes.
2. Armamentarium - the equipment and materials of the clinician
3. - immunomodulatory agents that alter the immune response by suppression or enhancement

In small studies, cooling techniques, or lowering the body temperature, has been reported to improve multiple symptoms among people with MS. In one such small study of eight patients, an improvement was seen in one patient’s ability to   more »